Process Development Group Leader in Cambridgeshire

Lead the Process Development group in the preclinical development of novel medicines comprising a consortium of live bacteria delivered orally to the intestinal tract. The successful candidate will actively contribute to the Company’s development programmes in ulcerative colitis and immune-oncology. The successful candidate will be responsible for in-house fermentation process development for multiple anaerobic gut bacteria that comprise the medicine, characterising and optimising their growth and providing support for upstream and downstream method development and optimisation.

Responsibilities:

  • Leading a small team to develop fermentation processes to produce live bacterial therapeutics comprising multiple bacterial strains
  • Performing anaerobic fermentation of bacteria from deep well blocks to small fermenters
  • Developing media screens and optimising media for growth of metabolically diverse bacteria
  • Co-ordinating outsourced lyophilisation development studies and developing an in-house capability for lyophilisation development.
  • Working closely with the assay development team to develop suitable assays to assess microbial cell quality
  • Maintaining an awareness of latest technologies and equipment for incorporation into company labs
  • Ensuring detailed records of experiments are kept within the team, suitable for supporting regulatory filings.
  • Supporting process transfer to CDMOs

Candidate Specifications:

 

Essential requirements for this post include:

  • PhD in relevant discipline eg: Microbiology or Bioprocess Engineering with focus on fermentation.
  • In-depth bacteriology knowledge
  • Post-doctoral experience in a bioprocess development environment utilising fermentation technology
  • Experience of optimising manufacturing processes and methodologies.
  • Strong leadership skills (Preferable experience of leading small teams).
  • Demonstrable initiative
  • Excellent communication and interpersonal skills.

 

Desirable requirements for this post include:

  • Experience of using Design of Experiments (DOE)
  • Previous experience working with a microbiome therapeutic or probiotic development company
  • Expertise in handling and culturing anaerobic bacteria
  • Experience of developing processes for subsequent application in GMP manufacture
  • Experience of process technology transfer to external companies
  • Experience of lyophilisation process development

If interested please send most recent CV to sarah.r@jobsinscience.com 

Reference

SR - PDGL

Location

Cambridgeshire
Chesterford, Cambridge

Salary

Competitive

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