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Principle Scientist Complex Biological Medicines in Darlington
As the Principal Scientist, you will act as a credible technical expert for the organisation, drawing upon a broad range of technical know-how to provide technical expertise and advice to a range of stakeholders, in order to inform technical strategy and direction.
Develop and optimise advanced processes for the conjugation, purification and formulation of drug conjugate products and molecular diagnostic systems.
Develop and optimise analytical methods to support characterization studies.
Scale-up processes and develop dossiers for transfer to GMP facilities where required.
Develop and optimise formulations.
To work as part of the programme team supporting the design and build of the new facility; specification and procurement of equipment and start-up the new facility.
To be responsible for building and managing a team of scientists responsible for starting up the new facility and delivering development projects.
To lead the technical delivery of development projects and providing specific technical support to the Business Development Team.
Educated to PHD/MSc level (or equivalent) in a Biochemistry, Chemistry, Chemical Engineering or related discipline.
A track-record of advanced conjugation chemistry and protein modification/purification experience.
Experience of protein/bioconjugate analysis, characterisation and quantitation by UV/Vis spectroscopy, size-exclusion/hydrophobic interaction/ion exchange chromatography, HPLC, LCMS and electrophoresis.
Ability to stay at the forefront of development techniques and methods and to enable innovation within both the team and projects.
Ability to plan and manage the execution of research and development projects in an effective and timely manner, including supervising, directing and mentoring the project team.
Ability to safely lead the installation and commissioning of equipment.
Laboratory management experience including writing standard operating procedures and protocols.
Experience of direct and indirect line management of up to 10 staff.
Project planning and delivery experience including liaising with customers and suppliers.
Experience of building projects with collaborators and customers.
Technical proposal and report writing.